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2007 Gilbert, D.M. (2007) Replication origin plasticity, Taylor-made: inhibition vs recruitment of origins under conditions of replication stress. Chromosoma 116: 341-347 Sasaki, T and Gilbert, D.M. (2007) The many faces of the origin recognition complex. Curr Opin Cell Biol. 19: 337-43. 2006 Sasaki T, Ramanathan S, Okuno Y, Kumagai C, Shaikh SS, Gilbert DM.(2006) The Chinese hamster dihydrofolate reductase replication origin decision point follows activation of transcription and suppresses initiation of replication within transcription units. Mol Cell Biol. 26(3):1051-62. Wu R, Singh PB, Gilbert DM.(2006) Uncoupling global and fine-tuning replication timing determinants for mouse pericentric heterochromatin. J Cell Biol. 174(2):185-94. Epub 2006 Jul 10. Wu, R., Terry, A. and Gilbert, D.M. (2006) Observing S-phase dynamics of histone modifications with fluorescently labeled antibodies. Methods Mol Biol. 325:139-48. 2005 Gilbert DM.(2005) Origins go plastic. Mol Cell. 20(5):657-8. Review. Panning MM, Gilbert DM. (2005) Spatio-temporal organization of DNA replication in murine embryonic stem, primary, and immortalized cells. J Cell Biochem.95(1):74-82. Wu R, Terry AV, Singh PB, Gilbert DM.(2005) Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states. Mol Biol Cell.16(6):2872-81. Epub 2005 Mar 23. McNairn AJ, Okuno Y, Misteli T, Gilbert DM.(2005) Chinese hamster ORC subunits dynamically associate with chromatin throughout the cell-cycle. Exp Cell Res.308(2):345-56. McNairn AJ, Gilbert DM.(2005) Overexpression of ORC subunits and increased ORC-chromatin association in transformed mammalian cells. J Cell Biochem. 96(5):879-87. 2004 Gilbert, D.M. (2004) In search of the holy replicator. Nat Rev Mol Cell Biol. Oct;5(10):848-55. Review Kourmouli, N., Jeppesen, P., Mahadevhiah, S., Burgoyne, P., Wu, R., Gilbert, D.M., Bongiorni, S., Prantera, G., Fanti, L., Pimpinelli, S., Shi, W., Fundele, R. and Singh, P.B. (2004) Heterochromatin and tri-methylated lysine 20 of histone H4 in animals. J. CELL SCI., 117(Pt 12):2491-501. Epub 2004 May 5. Hiratani I, Leskovar A, Gilbert DM.(2004)Differentiation-induced replication-timing changes are restricted to AT-rich/long interspersed nuclear element (LINE)-rich isochores.Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16861-6. Epub 2004 Nov 30 Angus, S.P, Mayhew, C.N., Solomon, D.A., Markey, M.P., Okuno, Y., Bartek, J., Cardoso, M.C., Gilbert, D.M and Knudsen E.S. (2004) RB reversibly inhibits DNA replication via two temporally distinct mechanisms. Mol. Cell. Biol., 24(12):5404-20. . Okuno, Y., Hahn, P.J. and Gilbert, D.M. (2004) Structure of a Palindromic Amplicon Junctin Implicates Microhomology-Mediated End Joining as a Mechanism of Sister Chromatid Fusion During Gene Amplification. NUCL. ACIDS RES. 32: 749-756. Bettinger, B., Gilbert, D.M. and Amberg, D.C. (2004) Actin Up in the Nucleus., NATURE REV. MOL. CELL BIOL. Kourmouli, N., Jeppesen, P., Mahadevhiah, S., Burgoyne, P., Wu, R., Gilbert, D.M., Bongiorni, S., Prantera, G., Fanti, L., Pimpinelli, S., Shi, W., Fundele, R. and Singh, P.B. (2004) Heterochromatin and tri-methylated lysine 20 of histone H4 in animals. J. CELL SCI., 117(Pt 12):2491-501. Epub 2004 May 5.. Gilbert, D.M. (2004) The Future of Human Embryonic Stem Cell Research: Addressing Ethical Conflict with Responsible Scientific Research. MED. SCI. MON., 10(5):RA99-103. Epub 2004 Apr 28.. 2003 McNairn, A.J. and Gilbert, D.M. (2003) Epigenomic Replication: linking epigenetics to DNA replication. BIOESSAYS 25(7): 647-56. Li, F., Chen, J. Solessio, E., and Gilbert, D.M. (2003) Spatial distribution and specification of mammalian replication origins during G1-phase. J. CELL BIOL. 161:257-266. McNairn, A.J. and Gilbert, D.M. (2003) Epigenomic Replication: linking epigenetics to DNA replication. BIOESSAYS 25(7): 647-56. Cheutin, T., McNairn, A.J., Jenuwein, T., Gilbert, D.M., Singh, P.B., Misteli, T. (2003) Maintenance of stable heterochromatin domains by dynamic HP1 binding. SCIENCE 299: 721-725. 2002 Keezer, S.M. and Gilbert, D.M. (2002) Sensitivity of the Origin Decision Point to Specific Inhibitors of Cellular Signaling and Metabolism, EXP. CELL RES. 273: 54-64. Gilbert, D.M. (2002) Replication timing and transcriptional control: beyond cause and effect. CURR. OPIN. CELL BIOL. 14: 377-383. Gilbert, D.M. (2002) The Evolution of Replication Timing. NATURE GENETICS 32:336-337. Cowell, I.G., Aucott, R., Mahadevaiah, S., Burgoyne, P.A., Huskisson, N., Bongiorni, S., Prantera, G. , Fanti, L., Pimpinelli, S., Wu, R., Gilbert, D.M., Shi, W., Fundele, R., Morrison, H., Jeppesen, P. and Singh, P.B. (2002) Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals, CHROMOSOMA 111: 22-36. Dimitrova, D.S., Prokhorova, T.A., Blow, J.J., Todorov, I. and Gilbert, D.M. (2002) Mammalian Nuclei Become Licensed for DNA Replication During Telophase, J. CELL SCI. 115: 51-59. Keezer, S.M. and Gilbert, D.M. (2002) Evidence for a Pre-Restriction Point Cdk3 Activity, J . CELLULAR BIOCHEM. 85: 545-552 2001 Okuno, Y., McNairn, A.J., den Elzen, N., Pines, J. and Gilbert, D.M. (2001) Stability, Chromatin- Association and Functional Activity of Mammalian Pre-Replication Complex Proteins During the Cell-Cycle, EMBO J. 20: 4263-4277. Gilbert, D. M. (2001) Making Sense of Eukaryotic Origins of Replication, SCIENCE 294: 96-100. Gilbert, D. M. (2001) Nuclear Position Leaves its Mark on Replication Timing, J. CELL BIOL. 152: F11-F15. Li, F., Chen, J., Izumi, M., Butler, M.C., Keezer, S. M. and Gilbert, D.M. (2001) The Replication Timing Program of the Chinese Hamster ?Globin Locus is Established Coincident With its Association With Peripheral Heterochromatin in Early G1-Phase, J. CELL BIOL. 154: 283-292. Feijoo, C., Hall-Jackson, C., Wu, R., Jenkins, D., Leitch, J., Gilbert, D.M. and Smythe, C (2001) Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra S-phase checkpoint monitoring replication origin firing. J. CELL BIOL. 154: 913-923. Okuno, Y., McNairn, A.J., den Elzen, N., Pines, J. and Gilbert, D.M. (2001) Stability, Chromatin- Association and Functional Activity of Mammalian Pre-Replication Complex Proteins During the Cell-Cycle, EMBO J. 20: 4263-4277. 2000 Wu, J.-W., Wang, J.-W. and Gilbert, D.M. (2000) Initiation Of DNA Replication In Saccharomyces Cerevisiae G1-Phase Nuclei By Xenopus Egg Extract, J. CELLULAR BIOCHEM. 80: 73-84. Wu, J.-W. and Gilbert, D.M. (2000) Lovastatin Arrests CHO Cells Between the Origin Decision Point and the Restriction Point, FEBS LETTERS 484: 108-112. Dimitrova, D.S. and Gilbert, D.M. (2000) Temporally Coordinated Assembly/Disassembly of Replication Factories in the Absence of DNA Synthesis, NATURE CELL BIOLOGY 2: 686-694. Dimitrova, D.S. and Gilbert, D.M. (2000) Stability and nuclear distribution of mammalian RPA heterotrimeric complex. EXP. CELL RES. 254: 321-327. Izumi, M, Whitfield, W. G. F., Hutchison, C. J. and Gilbert, D.M. (2000) Head and/or CaaX domain deletions of lamin proteins can disrupt pre-formed lamin A/C but not lamin B structure in mammalian cells, MOL. BIOL. CELL. 11: 4323-4337. 1999 Dimitrova, D.S., Todorov, I.T., Melendy, T. and Gilbert, D.M. (1999) Mcm2, But Not RPA, is a Component of the Mammalian Early G1-Phase pre-Replication Complex. J. CELL BIOL. 146: 1-14. Dimitrova, D.S. and Gilbert, D.M. (1999) DNA replication and nuclear organization: prospects for a soluble in vitro system. CRIT. REV. GENE EXP. 9: 353-361. Dimitrova, D.S. and Gilbert, D. M. (1999) The spatial position and replication timing of chromosomal domains are both established in early G1-phase. MOL. CELL 4: 983-993. Dimitrova, D.S., Todorov, I.T., Melendy, T. and Gilbert, D.M. (1999) Mcm2, But Not RPA, is a Component of the Mammalian Early G1-Phase pre-Replication Complex. J. CELL BIOL. 146: 1-14. Izumi, M and Gilbert, D.M. (1999) Homogeneous Tetracycline-Regulatable Gene Expression in Mammalian Fibroblasts, J. CELLULAR BIOCHEM. 76: 280-289. 1998 Gilbert, D.M. (1998) Replication origins in yeast versus metazoa: separation of the haves and the have nots. CURR. OPIN. GEN. DEV. 8: 194-199. Wu, J.-W. and Gilbert, D.M. (1998) Transformation Abrogates an Early G1-Phase Arrest Point Required for Specification of the Chinese Hamster DHFR Replication Origin EMBO J. 17: 1810 - 1818. Dimitrova, D.S and Gilbert, D.M. (1998) Regulation of Mammalian Replication Origin Usage in Xenopus Egg Extract. J. CELL SCI. 111: 2989-2998. Yu, G, Wu, J.-W. and Gilbert, D.M. (1998) Analysis of mammalian origin specification in ORCdepleted Xenopus egg extracts. GENES TO CELLS 3: 709-721. 1997 Wu, J.-W. and Gilbert, DM (1997) The Replication Origin Decision Point is a Mitogen Independent, 2- Aminopurine Sensitive, G1-Phase Event That Precedes Restriction Point Control. MOL. CELL. BIOL.17: 4312-4321. Wu, J.-W., Yu, G. and Gilbert, D.M. (1997) Origin-Specific Initiation of Mammalian Nuclear DNA Replication in a Xenopus Cell-Free System. METHODS, A Companion to Methods In Enzymology 13:313-324 1996 Wu, J.W. and Gilbert, D. M. (1996) A Distinct G1 Step Required to Specify A Mammalian Replication Origin SCIENCE 271: 1270-1272. Lawlis, SJ, Keezer, S.M., Wu, J.-R. and Gilbert, DM. (1996) Chromosome Architecture Can Dictate Site-specific Initiation of DNA Replication in Xenopus Egg Extracts J. CELL BIOL. 135: 1207-1218. 1995 Gilbert, D.M., Miyazawa, H. and DePamphilis, M.L. (1995) Site-specific initiation of DNA replication in Xenopus egg extracts requires nuclear structure. MOL. CELL. BIOL. 15, 2942-2954. Wu, J.W. and Gilbert, D. M. Rapid DNA preparation for 2D gel analysis of replication intermediates. (1995) NUCL. ACIDS RES. 23: 3997-3998. Gilbert, D.M., Neilson, A., Miyazawa, H., DePamphilis, M. L. and Burhans, W. C. (1995) Mimosine arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolism, J. BIOL. CHEM. 270, 9597-9606. 1993 Gilbert, D.M., Miyazawa, H., Nallaseth, F.S., Ortega, J.M., Blow, J.J. and DePamphilis, M.L. (1993) Site-specific initiation of DNA replication in metazoan chromsomes and the role of nuclear organization. COLD SPRING HARBOR SYMP. QUANT. BIOL. 58, 475-485. Gilbert D.M., Heery, D.M., Losson, R., Chambon, P. and Lemoine, Y. (1993) Estradiol-inducible squelching and cell growth arrest by a chimeric VP16-estrogen receptor expressed in Saccharomyces cerevisiae: suppression by an allele of PDR1. MOL. CELL. BIOL. 13, 462-472. 1992 Ravnan, J. B., Gilbert, D.M., Ten Hagen, K., and Cohen, S.N. (1992) Random-choice replication of extrachromosomal bovine papillomavirus (BPV) molecules in heterogeneous, clonally derived BPV-infected cell lines. J. VIROLOGY 66, 6946-6952. Gilbert, D.M., Hernandez, R. and Cohen, S.N. (1992) Mouse genomic DNA sequences homologous to sea urchin TU elements are genetically stable polydispersed repeats useful for analysis of multiple RFLP's. GENOMICS 12, 357-362. Gilbert, D.M., Losson, R. and Chambon, P.C. (1992) Ligand dependence of estrogen receptor induced changes in chromatin structure. NUCL. ACIDS RES. 20, 4525 - 4531. 1990 Gilbert, D.M. and Cohen, S.N. (1990) Position effects on the timing of replication of chromosomally integrated simian virus 40 molecules in chinese hamster cells. MOL. CELL. BIOL 10, 4345-4355. Ten-Hagen, K., Gilbert, D.M., Willard, H. and Cohen, S.N. (1990) Replication timing of DNA sequences associated with human centromeres and telomeres. MOL. CELL. BIOL. 10, 6348-6355. 1988 Gilbert, D.M. and Cohen, S. N. (1988) Autonomous replication in mouse cells. CELL 56, 143-144. 1987 Gilbert, D.M. and Cohen, S.N. (1987) Bovine papilloma virus plasmids replicate randomly in mouse fibroblasts throughout S-phase of the cell cycle. CELL 50, 59-68. Hertel-Wulff, B., Lindsten, T., Schwadron, R., Gilbert, D.M., Davis, M. and Strober, S. (1987) Rearrangement and expression of T-cell receptor genes in cloned murine natural suppressor cell lines. J . EXP. MED. 166, 1168-1173. 1986 Gilbert, D.M. (1986) Temporal order of replication of Xenopus laevis 5S ribosomal RNA genes in somatic cells. PROC. NAT. ACAD. SCI. USA 83, 2924-2928.