| Replication Origins |
|
Gilbert, D.M. and Cohen, S.N. (1987) Bovine papilloma virus plasmids replicate randomly in mouse
fibroblasts throughout S-phase of the cell cycle. CELL 50, 59-68.
|
|
Gilbert, D.M. and Cohen, S. N. (1988) Autonomous replication in mouse cells. CELL 56, 143-144.
|
|
Ravnan, J. B., Gilbert, D.M., Ten Hagen, K., and Cohen, S.N. (1992) Random-choice replication of
extrachromosomal bovine papillomavirus (BPV) molecules in heterogeneous, clonally derived BPV-infected
cell lines. J. VIROLOGY 66, 6946-6952.
|
|
Gilbert, D.M., Miyazawa, H., Nallaseth, F.S., Ortega, J.M., Blow, J.J. and DePamphilis, M.L. (1993)
Site-specific initiation of DNA replication in metazoan chromsomes and the role of nuclear organization.
COLD SPRING HARBOR SYMP. QUANT. BIOL. 58, 475-485.
|
|
Gilbert, D.M., Miyazawa, H. and DePamphilis, M.L. (1995) Site-specific initiation of DNA replication
in Xenopus egg extracts requires nuclear structure. MOL. CELL. BIOL. 15, 2942-2954.
|
|
Wu, J.W. and Gilbert, D. M. Rapid DNA preparation for 2D gel analysis of replication intermediates.
(1995) NUCL. ACIDS RES. 23: 3997-3998.
|
|
Wu, J.W. and Gilbert, D. M. (1996) A Distinct G1 Step Required to Specify A Mammalian Replication
Origin SCIENCE 271: 1270-1272.
|
|
Lawlis, SJ, Keezer, S.M., Wu, J.-R. and Gilbert, DM. (1996) Chromosome Architecture Can Dictate
Site-specific Initiation of DNA Replication in Xenopus Egg Extracts J. CELL BIOL. 135: 1207-1218.
|
|
Wu, J.-W. and Gilbert, DM (1997) The Replication Origin Decision Point is a Mitogen Independent, 2-
Aminopurine Sensitive, G1-Phase Event That Precedes Restriction Point Control. MOL. CELL.
BIOL.17: 4312-4321.
|
|
Wu, J.-W., Yu, G. and Gilbert, D.M. (1997) Origin-Specific Initiation of Mammalian Nuclear DNA
Replication in a Xenopus Cell-Free System. METHODS, A Companion to Methods In
Enzymology 13:313-324
|
|
Gilbert, D.M. (1998) Replication origins in yeast versus metazoa: separation of the haves and the have
nots. CURR. OPIN. GEN. DEV. 8: 194-199.
|
|
Wu, J.-W. and Gilbert, D.M. (1998) Transformation Abrogates an Early G1-Phase Arrest Point
Required for Specification of the Chinese Hamster DHFR Replication Origin EMBO J. 17: 1810 - 1818.
|
|
Dimitrova, D.S and Gilbert, D.M. (1998) Regulation of Mammalian Replication Origin Usage in
Xenopus Egg Extract. J. CELL SCI. 111: 2989-2998.
|
|
Yu, G, Wu, J.-W. and Gilbert, D.M. (1998) Analysis of mammalian origin specification in ORCdepleted
Xenopus egg extracts. GENES TO CELLS 3: 709-721.
|
|
Dimitrova, D.S., Todorov, I.T., Melendy, T. and Gilbert, D.M. (1999) Mcm2, But Not RPA, is a
Component of the Mammalian Early G1-Phase pre-Replication Complex. J. CELL BIOL. 146: 1-14.
|
|
Dimitrova, D.S. and Gilbert, D.M. (1999) DNA replication and nuclear organization: prospects for a
soluble in vitro system. CRIT. REV. GENE EXP. 9: 353-361.
|
|
Wu, J.-W., Wang, J.-W. and Gilbert, D.M. (2000) Initiation Of DNA Replication In Saccharomyces
Cerevisiae G1-Phase Nuclei By Xenopus Egg Extract, J. CELLULAR BIOCHEM. 80: 73-84.
|
|
Wu, J.-W. and Gilbert, D.M. (2000) Lovastatin Arrests CHO Cells Between the Origin Decision Point
and the Restriction Point, FEBS LETTERS 484: 108-112.
|
|
Okuno, Y., McNairn, A.J., den Elzen, N., Pines, J. and Gilbert, D.M. (2001) Stability, Chromatin-
Association and Functional Activity of Mammalian Pre-Replication Complex Proteins During the Cell-Cycle,
EMBO J. 20: 4263-4277.
|
|
Gilbert, D. M. (2001) Making Sense of Eukaryotic Origins of Replication, SCIENCE 294: 96-100.
|
|
Keezer, S.M. and Gilbert, D.M. (2002) Sensitivity of the Origin Decision Point to Specific Inhibitors of
Cellular Signaling and Metabolism, EXP. CELL RES. 273: 54-64.
|
|
McNairn, A.J. and Gilbert, D.M. (2003) Epigenomic Replication: linking epigenetics to DNA replication.
BIOESSAYS 25(7): 647-56.
|
|
Li, F., Chen, J. Solessio, E., and Gilbert, D.M. (2003) Spatial distribution and specification of
mammalian replication origins during G1-phase. J. CELL BIOL. 161:257-266.
|
|
Gilbert, D.M. (2004) In search of the holy replicator.
Nat Rev Mol Cell Biol. Oct;5(10):848-55. Review
|
|
Gilbert DM.(2005) Origins go plastic.
Mol Cell. 20(5):657-8. Review.
|
|
Sasaki T, Ramanathan S, Okuno Y, Kumagai C, Shaikh SS, Gilbert DM.(2006) The Chinese hamster dihydrofolate reductase replication origin decision point follows activation of transcription and suppresses initiation of replication within transcription units.
Mol Cell Biol. 26(3):1051-62.
|
| Replication Timing |
|
Gilbert, D.M. (1986) Temporal order of replication of Xenopus laevis 5S ribosomal RNA genes in
somatic cells. PROC. NAT. ACAD. SCI. USA 83, 2924-2928.
|
|
Gilbert, D.M. and Cohen, S.N. (1990) Position effects on the timing of replication of chromosomally
integrated simian virus 40 molecules in chinese hamster cells. MOL. CELL. BIOL 10, 4345-4355.
|
|
Ten-Hagen, K., Gilbert, D.M., Willard, H. and Cohen, S.N. (1990) Replication timing of DNA
sequences associated with human centromeres and telomeres. MOL. CELL. BIOL. 10, 6348-6355.
|
|
Dimitrova, D.S. and Gilbert, D. M. (1999) The spatial position and replication timing of chromosomal
domains are both established in early G1-phase. MOL. CELL 4: 983-993.
|
|
Gilbert, D. M. (2001) Nuclear Position Leaves its Mark on Replication Timing, J. CELL BIOL. 152:
F11-F15.
|
|
Li, F., Chen, J., Izumi, M., Butler, M.C., Keezer, S. M. and Gilbert, D.M. (2001) The Replication
Timing Program of the Chinese Hamster ?Globin Locus is Established Coincident With its Association
With Peripheral Heterochromatin in Early G1-Phase, J. CELL BIOL. 154: 283-292.
|
|
Gilbert, D.M. (2002) Replication timing and transcriptional control: beyond cause and effect. CURR.
OPIN. CELL BIOL. 14: 377-383.
|
|
Gilbert, D.M. (2002) The Evolution of Replication Timing. NATURE GENETICS 32:336-337.
|
|
Cowell, I.G., Aucott, R., Mahadevaiah, S., Burgoyne, P.A., Huskisson, N., Bongiorni, S., Prantera, G. ,
Fanti, L., Pimpinelli, S., Wu, R., Gilbert, D.M., Shi, W., Fundele, R., Morrison, H., Jeppesen, P. and
Singh, P.B. (2002) Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals,
CHROMOSOMA 111: 22-36.
|
|
Li, F., Chen, J. Solessio, E., and Gilbert, D.M. (2003) Spatial distribution and specification of
mammalian replication origins during G1-phase. J. CELL BIOL. 161:257-266.
|
|
McNairn, A.J. and Gilbert, D.M. (2003) Epigenomic Replication: linking epigenetics to DNA replication.
BIOESSAYS 25(7): 647-56.
|
|
Kourmouli, N., Jeppesen, P., Mahadevhiah, S., Burgoyne, P., Wu, R., Gilbert, D.M., Bongiorni, S.,
Prantera, G., Fanti, L., Pimpinelli, S., Shi, W., Fundele, R. and Singh, P.B. (2004) Heterochromatin and
tri-methylated lysine 20 of histone H4 in animals. J. CELL SCI., 117(Pt 12):2491-501. Epub 2004 May 5.
|
Hiratani I, Leskovar A, Gilbert DM.(2004)Differentiation-induced replication-timing changes are restricted to AT-rich/long interspersed nuclear element (LINE)-rich isochores.Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16861-6. Epub 2004 Nov 30 |
|
Panning MM, Gilbert DM. (2005) Spatio-temporal organization of DNA replication in murine embryonic stem, primary, and immortalized cells.
J Cell Biochem.95(1):74-82.
|
|
Wu R, Terry AV, Singh PB, Gilbert DM.(2005) Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states.
Mol Biol Cell.16(6):2872-81. Epub 2005 Mar 23.
|
|
Wu R, Singh PB, Gilbert DM.(2006) Uncoupling global and fine-tuning replication timing determinants for mouse pericentric heterochromatin.
J Cell Biol. 174(2):185-94. Epub 2006 Jul 10.
|
| Check Point |
|
Dimitrova, D.S. and Gilbert, D.M. (2000) Temporally Coordinated Assembly/Disassembly of
Replication Factories in the Absence of DNA Synthesis, NATURE CELL BIOLOGY 2: 686-694.
|
|
Feijoo, C., Hall-Jackson, C., Wu, R., Jenkins, D., Leitch, J., Gilbert, D.M. and Smythe, C (2001)
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra S-phase
checkpoint monitoring replication origin firing. J. CELL BIOL. 154: 913-923.
|
|
Angus, S.P, Mayhew, C.N., Solomon, D.A., Markey, M.P., Okuno, Y., Bartek, J., Cardoso, M.C., Gilbert,
D.M and Knudsen E.S. (2004) RB reversibly inhibits DNA replication via two temporally distinct
mechanisms. Mol. Cell. Biol., 24(12):5404-20.
.
|
| Pre-RC |
|
Yu, G, Wu, J.-W. and Gilbert, D.M. (1998) Analysis of mammalian origin specification in ORCdepleted
Xenopus egg extracts. GENES TO CELLS 3: 709-721.
|
|
Dimitrova, D.S., Todorov, I.T., Melendy, T. and Gilbert, D.M. (1999) Mcm2, But Not RPA, is a
Component of the Mammalian Early G1-Phase pre-Replication Complex. J. CELL BIOL. 146: 1-14.
|
|
Okuno, Y., McNairn, A.J., den Elzen, N., Pines, J. and Gilbert, D.M. (2001) Stability, Chromatin-
Association and Functional Activity of Mammalian Pre-Replication Complex Proteins During the Cell-Cycle,
EMBO J. 20: 4263-4277.
|
|
Dimitrova, D.S., Prokhorova, T.A., Blow, J.J., Todorov, I. and Gilbert, D.M. (2002) Mammalian
Nuclei Become Licensed for DNA Replication During Telophase, J. CELL SCI. 115: 51-59.
|
|
McNairn AJ, Okuno Y, Misteli T, Gilbert DM.(2005) Chinese hamster ORC subunits dynamically associate with chromatin throughout the cell-cycle.
Exp Cell Res.308(2):345-56.
|
|
McNairn AJ, Gilbert DM.(2005) Overexpression of ORC subunits and increased ORC-chromatin association in transformed mammalian cells.
J Cell Biochem. 96(5):879-87.
|
| MISCELLANEOUS |
|
Hertel-Wulff, B., Lindsten, T., Schwadron, R., Gilbert, D.M., Davis, M. and Strober, S. (1987)
Rearrangement and expression of T-cell receptor genes in cloned murine natural suppressor cell lines. J .
EXP. MED. 166, 1168-1173.
|
|
Gilbert, D.M., Hernandez, R. and Cohen, S.N. (1992) Mouse genomic DNA sequences homologous to
sea urchin TU elements are genetically stable polydispersed repeats useful for analysis of multiple RFLP's.
GENOMICS 12, 357-362.
|
|
Gilbert, D.M., Losson, R. and Chambon, P.C. (1992) Ligand dependence of estrogen receptor induced
changes in chromatin structure. NUCL. ACIDS RES. 20, 4525 - 4531.
|
|
Gilbert D.M., Heery, D.M., Losson, R., Chambon, P. and Lemoine, Y. (1993) Estradiol-inducible
squelching and cell growth arrest by a chimeric VP16-estrogen receptor expressed in Saccharomyces
cerevisiae: suppression by an allele of PDR1. MOL. CELL. BIOL. 13, 462-472.
|
|
Gilbert, D.M., Neilson, A., Miyazawa, H., DePamphilis, M. L. and Burhans, W. C. (1995) Mimosine
arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolism, J. BIOL.
CHEM. 270, 9597-9606.
|
|
Izumi, M and Gilbert, D.M. (1999) Homogeneous Tetracycline-Regulatable Gene Expression in
Mammalian Fibroblasts, J. CELLULAR BIOCHEM. 76: 280-289.
|
|
Dimitrova, D.S. and Gilbert, D.M. (2000) Stability and nuclear distribution of mammalian RPA
heterotrimeric complex. EXP. CELL RES. 254: 321-327.
|
|
Izumi, M, Whitfield, W. G. F., Hutchison, C. J. and Gilbert, D.M. (2000) Head and/or CaaX domain
deletions of lamin proteins can disrupt pre-formed lamin A/C but not lamin B structure in mammalian cells,
MOL. BIOL. CELL. 11: 4323-4337.
|
|
Keezer, S.M. and Gilbert, D.M. (2002) Evidence for a Pre-Restriction Point Cdk3 Activity, J .
CELLULAR BIOCHEM. 85: 545-552
|
|
Cheutin, T., McNairn, A.J., Jenuwein, T., Gilbert, D.M., Singh, P.B., Misteli, T. (2003) Maintenance
of stable heterochromatin domains by dynamic HP1 binding. SCIENCE 299: 721-725.
|
|
Okuno, Y., Hahn, P.J. and Gilbert, D.M. (2004) Structure of a Palindromic Amplicon Junctin Implicates
Microhomology-Mediated End Joining as a Mechanism of Sister Chromatid Fusion During Gene
Amplification. NUCL. ACIDS RES. 32: 749-756.
|
|
Bettinger, B., Gilbert, D.M. and Amberg, D.C. (2004) Actin Up in the Nucleus., NATURE REV.
MOL. CELL BIOL.
|
|
Kourmouli, N., Jeppesen, P., Mahadevhiah, S., Burgoyne, P., Wu, R., Gilbert, D.M., Bongiorni, S.,
Prantera, G., Fanti, L., Pimpinelli, S., Shi, W., Fundele, R. and Singh, P.B. (2004) Heterochromatin and
tri-methylated lysine 20 of histone H4 in animals. J. CELL SCI., 117(Pt 12):2491-501. Epub 2004 May 5..
|
|
Gilbert, D.M. (2004) The Future of Human Embryonic Stem Cell Research: Addressing Ethical
Conflict with Responsible Scientific Research. MED. SCI. MON., 10(5):RA99-103. Epub 2004 Apr 28..
|
| Methods Paper |
|
Wu, J.-W. and Gilbert, DM (1997) The Replication Origin Decision Point is a Mitogen Independent, 2-
Aminopurine Sensitive, G1-Phase Event That Precedes Restriction Point Control. MOL. CELL. BIOL.17: 4312-4321.
|
|
Wu, R., Terry, A. and Gilbert, D.M. (2006) Observing S-phase dynamics of histone modifications with fluorescently labeled antibodies. Methods Mol Biol. 325:139-48.
|
|
Yokochi T and Gilbert DM. (2006) Replication labeling with halogenated thymidine analogues. Current Protocols in Cell Biology. In press. Methods Mol Biol. 325:139-48.
|
| Review Articles |
|
Gilbert, D.M. (2002) The Evolution of Replication Timing. NATURE GENETICS 32:336-337.
|
|
Gilbert, D.M. (2004) In search of the holy replicator.
Nat Rev Mol Cell Biol. Oct;5(10):848-55. Review
|
|
Gilbert DM.(2005) Origins go plastic.
Mol Cell. 20(5):657-8. Review. |
|
Gilbert, D.M. and Gasser, S.M. (2006) Nuclear Structure and DNA Replication. In: Eukaryotic DNA Replication. CSH Press (ed. Melvin L. DePamphilis)
|
|
Gilbert, D.M. (2007) Replication origin plasticity, Taylor-made: inhibition vs recruitment of origins under conditions of replication stress. Chromosoma 116: 341-347
|
|
Sasaki, T and Gilbert, D.M. (2007) The many faces of the origin recognition complex. Curr Opin Cell Biol. 19: 337-43.
|
|
