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The Florida State University

David M. Gilbert

Our goal is to understand how mammalian chromosomes are organized within the nucleus to carry out their functions. DNA replication provides an excellent forum in which to study chromosome structure and function. Structural and functional units of chromosomes replicate coordinately, often through the synchronous firing of clusters of replication origins that encompass domains of approximately 0.5 Mb. Each of these replication domains is programmed to replicate at a specific time during S-phase. In general, transcriptionally active (euchromatin) domains replicate early in S-phase, and transcriptionally silent (heterochromatin) domains replicate late. Programmed changes in replication timing accompany key stages of animal development and are often coupled to changes in gene expression. Our working hypothesis is that structural, functional, and replication domains share topographical boundaries and represent basic units of chromosome organization. We would like to understand what regulates where and when replication begins, how developmental cues communicate with the cell-cycle machinery to elicit changes in the program for replication and how that program is disrupted in cancer.

Read more

Interview with Dr. Gilbert (MP4 Video)

In Search of lost timing (PDF)

Cold Spring Harbor Symposium 2010 (MP4 Video)

Cold Spring Harbor Symposium 2013 (MP4 Video)

Cold Spring Harbor Symposium 2015 (MP4 Video)

Cold Spring Harbor Symposium 2017 (MP4 Video)

Cold Spring Harbor Symposium 2018 (MP4 Video)

DCMB Seminar 2015 (MP4 Video)


About David M. Gilbert

  • J Herbert Taylor Distinguished Professor of Molecular Biology 
  • FSU Biology Pfeiffer Endowed Professorship for Cancer Research 
  • FSU 2015 Distinguished Research Professor 
  • FSU 2016 Graduate Mentorship award 
  • Fellow , American Association for the Advancement of Science 
  • Associate Director of the Center for Genomics and Personalized Medicine 

  • Ph.D., 1989, Stanford University 
  • Postdoctoral Fellows:
    • Faculté de Médecine, FRANCE
    • Roche Institute of Molecular Biology

Interests & Resume

  • Structure and replication of chromosomes in stem cells and cancer
  • NIH Biographical sketch
    In pdf format

Contact Information