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Current Lab Members


Name: Takayo Sasaki (she/her/hers)
Email: sasakit@bio.fsu.edu
Position: Laboratory Manager and Associate in Research
Interests: I have a broad interest and experience in cell and molecular biology, especially mammalian cell cycle and DNA replication. I joined Gilbert lab as a post-doc in 2001. In recent years, about half of my time is spent for laboratory management/administration but I still develop and optimize replication timing assay, replication foci observation.


Name: Kyle Klein (he/him/his)
Email: kklein@bio.fsu.edu
Position: Post-doc
Interests: My research is focused on the human protein RIF1 that controls the genome wide replication timing program and understanding the consequences of genome scale replication timing defects. I am also developing tools to study replication initiation at the level of single DNA fibers.


Name: Daniel Bartlett (he/him/his)
Email: dbartlett@bio.fsu.edu
Position: Graduate Student
Interests: I have broad interests in DNA replication, nuclear architecture, epigenomics and single-cell genomics. The principle objective of my PhD thesis is to extensively map DNA replication protein binding sites throughout the human genome to identify chromatin features influencing pre-replication complex assembly sites and initiation frequencies, and to present a comprehensive view of how DNA replication is globally coordinated with other cell-type specific functions such as transcription and genome architecture. To this end, I have recently invented a novel method capable of profiling the genome-wide epigenetic landscape in single human cells. In my free time I like to bicycle, rock climb, camp, make music, and build/repair/overhaul an assortment of random possessions.


Name: Peiyao Zhao
Email: pzhao@bio.fsu.edu
Position: Graduate Student
Interests: My project focuses on the bioinformatic analyses of high-resolution Repli-seq and its integration with other datatypes investigating the multitude of chromatin features. I am also interested in the investigation of the roles of the omnipotent gene RIF1 in orchestrating a correct RT programme in mammalian cells and the chromatin level consequences of a disrupted RT programme. I did my undergrad studies in University of Oxford in England and grew up in the very fashionable town that is Brighton. I enjoy literature, theatre and all things camp and glittery.


Name: Jesse Turner (he/him/his)
Email: jturner@bio.fsu.edu
Position: Graduate Student
Interests: I am interested in the 3D organization of chromatin within the nucleus and how that relates to other nuclear activities, such as transcription and DNA replication. My current project in the lab is investigating early replication control elements (ERCEs) and the minimal sequences necessary for their activity within the Dppa2/4 and Rex1 domains in mouse embryonic stem cells. Currently, we know that there are three large sequences that we have identified as being necessary for early replication, transcription, TAD architecture, and sub-nuclear compartmentalization of the Dppa2/4 domain, and two more in the Rex1 domain. I am currently attempting to trim down these deletions and identify the specific sequences responsible for this activity. Outside of the lab, I enjoy watching my Baltimore Ravens on Sunday and Monday nights, supporting the University of Maryland in all of their events (GO TERPS!!), playing sports (the biology department has a pretty sick kickball team).


Name: Athanasios "Ethan" Vouzas (he/him/his)
Email: avouzas@bio.fsu.edu
Position: Graduate student
Interests: Currently, I am interested in the relationship between the regulation of transcription and the regulation of replication timing (RT). The correlation between transcription and early replication is evident, however, the causal link between the two remains elusive. To shed light into this relationship, I am inserting various artificial transcriptional regulatory elements both in defined loci in the genome (Ptn and Pcdh9) , utilizing CRISPR/Cas9 genome editing tools, as well as at random loci genome wide, using a PiggyBac transposase system. Additionally, I am investigating whether elements associated with active transcription, such as H3K27Ac, are influencing the RT of a given locus.


Name: Madelyn Dotson (she/her/hers)
Email: mrd14e@my.fsu.edu
Position: Lab Technician
Interests: I am inserting Early Replication Control Elements (ERCEs) into ectopic sites to evaluate their sufficiency to advance DNA replication timing at various loci. I have also begun to use live cell imaging to track replication timing of two alleles of the same loci in asynchronously replicating regions. After gaining experience in the Gilbert Lab I plan to pursue my PhD.


Name: Nicolas Holcomb (he/him/his)
Email: nph15@my.fsu.edu
Position: Lab Technician
Interests: I am testing the hypothesis that Early Replication Control Elements (ERCEs) are cell type specific by using parameters for their identification that were worked out in embryonic stem cells to identify neural-specific ERCEs in neural precursor cells. This involves identifying central regulators in transcriptional regulatory networks and integrating their binding sites with histone modifications and 3D interaction profiles. In my free time, I like to play basketball, games or hang out with friends.


Name: Isabel Jarmel (she/her/hers)
Email: iaj17@my.fsu.edu
Position: Undergraduate Student
Interests: I am studying the effects that the Rif1 protein has on DNA repair pathways and its potential use in improving genome engineering methods. In my free time, I love to play the guitar and write music.


Name: Alexis Molina (she/her/hers)
Email: am17x@my.fsu.edu
Position: Undergraduate Student
Interests: I am using the PiggyBac transposase to integrate DNA sequences suspected to advance replication timing into many different sites within the same clonal population of cells. I am hoping that this will allow us to measure the effects of different chromosome domains on the activities of elements that can influence replication timing.


Name: Kristina Lynch (she/her/hers)
Email: kml17f@my.fsu.edu
Position: Undergraduate Student
Interests: My project in the lab involves using microscopy to visualize DNA replication foci patterns and to observe their pattern changes as the cells progress through S phase. In addition to completing research in the lab I am also a member of the FSU Women's Soccer Team. I aspire to play soccer professionally and to have a career in medicine and research.


Name: Ana Delgado (she/her/hers)
Email: agd18d@my.fsu.edu
Position: Work Study

Name: David M. Gilbert
Position: Professor


About David M. Gilbert
  •  J Herbert Taylor Distinguished Professor of Molecular Biology 
  •  FSU Biology Pfeiffer Endowed Professorship for Cancer Research 
  •  FSU 2015 Distinguished Research Professor 
  •  FSU 2016 Graduate Mentorship award 
  •  Fellow , American Association for the Advancement of Science 
  •  Associate Director of the  Center for Genomics and Personalized Medicine 
  •  Ph.D., 1989, Stanford University 
  • Postdoctoral Fellows:
    •     Faculté de Médecine, FRANCE
    •     Roche Institute of Molecular Biology
Interests and Resume
   Address Information

  •         Building: KIN3066
  •         Phone: 850-645-7583
  •         Email: gilbert@bio.fsu.edu
  •         Fax: 850-645-8447